How Does PRP Treatment Work?


Injections of platelet-rich plasma (PRP), which is high in growth factors that promote tissue repair and healing, may aid in the healing of damaged regions. Get the Best information about PRP treatment.

Your doctor will take a small sample of your blood, spin it to extract the plasma, and then inject the PRP directly into the damaged area using ultrasound guidance or other imaging technology.


Growth factors included in platelet-rich plasma encourage and augment your body’s production of reparative cells. As a result, PRP therapy can accelerate the healing of tennis elbow tendons as well as alleviate pain associated with other muscle and skeletal conditions like fibromyalgia or sprained ankles. In this video, HSS sports medicine specialist Brian D. Halpern explains how it operates.

PRP involves collecting blood for treatment and then isolating its platelet-rich portion before injecting it directly into an area of injury or pain. A doctor numbs the area before initiating injections using ultrasound imaging; using this technology, they can pinpoint exactly where these injections should take place.

PRP injections have proven helpful in treating many conditions, from hair loss and arthritis to hair thinning and arthritis. According to one 2015 study, men who received PRP injections for thinning hair experienced more new hair growth than those who didn’t get PRP shots.

Platelet-rich plasma (PRP) contains leukocytes that can positively influence intrinsic biological processes in chronic soft tissue lesions, including vascularization and wound healing, cell differentiation, and reduction of alkaline phosphatase levels. Studies have revealed that PRP physical preparations containing leukocytes are more effective at stimulating angiogenesis than PRP without leukocytes, as these induce cell senescence (when cells cease dividing but still display distinctive phenotypic changes that prevent unrestricted cell proliferation). Additionally, concentrations of platelets and leukocytes influence how angiogenesis manifests itself in terms of the magnitude or complexity of angiogenesis.

Side effects

Plasma in your blood is predominantly liquid, providing a transport vehicle for red and white cells, as well as platelets, to move throughout your body. Although platelets are well recognized for their ability to aid in blood clotting, they also contain hundreds of proteins called growth factors that are essential to the healing process. PRP contains more platelets than what would usually be found in your blood, leading to an increased concentration of growth factors, which helps promote healing.

Doctors have discovered that when used to repair muscle injuries, PRP’s growth factors aid satellite cell activation and myogenesis. Furthermore, they can increase levels of anti-inflammatory cytokines, which reduce inflammation to make muscles feel less sore post-exercise.

In order to provide therapeutic benefits, PRP injections can be directly given into wounded or inflammatory tissue areas. This usually doesn’t cause discomfort; however, there may be slight bruising and swelling at the injection site. Because blood is drawn for testing purposes, eating before coming in will prevent feeling lightheaded during your appointment.

An infection at the injection site may arise if you fail to heed your doctor’s pre-treatment preparation instructions. It is essential to refrain from taking blood-thinning drugs like ibuprofen and aspirin as well as omega-3 fatty acid supplements for 72 hours post-treatment; coloring your hair or getting it permed can irritate the skin at the injection site, exacerbating any pain from PRP therapy treatments.


Medical professionals will collect a sample of your blood and use a machine to isolate and separate platelet-rich plasma from the rest. They then numb the area in need of treatment before injecting this treatment with plasma injections, typically taking approximately 30 minutes.

Concentrated platelets, which are tiny cells that aid in healing and cell division, are present in PRP along with unique substances referred to as growth factors. Doctors can more rapidly and efficiently increase the number of PRP injections to wounded tissues in order to expedite the healing process.

Platelet-rich plasma also has another valuable property: It can help reduce inflammation in the body. One approach for doing this is by extracting white blood cells from PRP formulation, thus producing leukocyte-poor PRP that provides anti-inflammatory benefits.

Platelet-rich plasma (PRP) therapy can be an effective means of treating injuries to ligaments, tendons, and muscles. Typical applications include treating tennis elbow and Achilles tendinitis as well as chronic injuries to the musculoskeletal system, such as knee arthritis.


PRP treatment typically does not require much downtime after administration, although mild soreness at the injection site for two to three days after administration can often be managed with pain medications if necessary. Most physicians advise taking it easy following PRP administration, including wearing loose-fitting clothing so as not to strain treated areas during recovery.

Healthcare providers will clean the treatment area and use a local anesthetic if needed to reduce discomfort before giving PRP injections. Plasma will be further separated and concentrated by raising the concentration of platelets within it after being separated and concentrated using a centrifuge machine once this concentrated plasma has been prepared for injection directly into any desired treatment areas, such as joints, tendons, or scalp areas by doctors.

As the plasma contains cells from within each patient’s own body, there is minimal risk of their body rejecting or reacting adversely to an injection. There may, however, be an infection at the injection site; therefore, patients must refrain from taking NSAIDs or Aspirin at least ten days before their appointment as these medications could decrease the effectiveness of treatment and stop using blood-thinning supplements or herbs at least one week prior.

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